StraighterLine
Course Structure:
StraighterLine's course structure has 4 quizzes per class, which are 25 questions per quiz. This means only 100 questions on their quizzes total, whereas Study.com will have 500ish. However, these questions are slightly more difficult, and will require a bit more studying.
Here's how the grade scoring system on StraighterLine works works, find the Syllabus of the class you are taking and see how many points the Quizzes and Final are worth.
The Quizzes plus Non-Proctored Midterm Exam add up to 700 points and the Final is worth 300 points. Therefore, if you get 100% on all the exams, you can realistically get 0% on the Final. This is one of the things that makes StraighterLine interesting, and one of the reasons I recommend doing Math courses on their platform over Study.com and Sophia.org.

This is how most classes are structured, but not all of them. The Quizzes and Non-Proctored Midterm Exam are worth 700 total points and Final is worth 300 points.
User Interface:
StraighterLine provides a modern looking website that looks clean and straight-forward. I would prefer a dark-theme, but Study and Sophia don't have that either. Overall, it should be easy on the eyes so you can get some work done and enjoy the aesthetics in the process.
Pricing Model:
StraighterLine cost $99 a month, however, no classes come for free like Study.com's and Sophia does. Each class, is on average, $79. One cool thing on StraighterLine is there is no maximum amount of classes, you can take as many as you want in a month, as long as you keep paying. So StraighterLine can actually save you a ton of money if you do a lot of classes in a month.
Is StraighterLine Proctored?
Yes. It is the only website of the three that is proctored. It is a quick and easy process though. You schedule a test for 72 hours in advance, or pay $8 for an instant schedule. The proctor company is ProctorU and my experience was 99% positive. Out of the 20+ Proctors I had, I only had one bad experience, possibly from someone just having a bad day. Plus if you get 95%+ on the assignments and tests, you can basically fail the proctored final and likely still pass the class.
Average Course Length:
StraighterLine can be done even faster than Study.com or Sophia although might cost a bit more overall, slightly. If speed is what you want, StraighterLine is for you.